Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

► Effect of cholesterol on antimicrobial peptide induced membrane disruption in different lipid phases was tested. ► Cholesterol had no effect on the AMP-induced membrane disruption in liquid disordered phase. ► Formation of liquid ordered phase by cholesterol strongly inhibited membrane disruption by an AMP. ► Cholesterol had no effect on the disruption of raft membranes with liquid ordered-liquid disordered coexistence.