Aggregation behavior of ibuprofen, cholic acid and dodecylphosphocholine micelles

► Ibuprofen (an NSAID) and cholic acid (a bile acid) form mixed micelles that are toxic to the intestine. ► The size of these micelles varies non-linearly with the molar ratio of the reactants. ► Pre-formed dodecylphosphocholine micelle alters the size of the NSAID-cholic acid micelles.