The over-expression of TRPC6 channels in HEK-293 cells favours the intracellular accumulation of zinc

► TRPC6 proteins form cation channels found in many tissues and organs. ► The over-expression of TRPC6 channels causes an intracellular accumulation of Zinc. ► The entry of Zn2+ through TRPC6 regulates the size of internal pools of Zn2+. ► Our data unveil an unanticipated role of TRPC6 in cellular zinc homeostasis.