Compatible solutes: Ectoine and hydroxyectoine improve functional nanostructures in artificial lung surfactants

►Ectoine and hydroxyectoine are produced by bacteria and have water binding property. ►They act on line tension of lipid-protein membranes and alter the domain organization. ►They enhance the protrusion formation in artificial LS favoring the breathing process. ►Vesicle insertion into the surfactant monolayer is accelerated by compatible solutes.