Protein palmitoylation and subcellular trafficking

► We describe herein the palmitoylation and trafficking of every small GTPase of the Ras and Rho families. ► Golgi-localized palmitoyl transferases of the DHHC family regulate palmitoylation cycles. ► Palmitoylation of eNOS and iNOS regulates their subcellular traffic. ► Surfactant protein C requires palmitoylation for activity but not for sorting.