Kiss your tail goodbye: The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology

► PARN deadenylase binds to mRNA 5′ caps with functional and biological implications. ► PARN plays a role in early development, DNA damage and possibly cancer. ► Nocturnin deadenylase shows rhythmic expression under circadian control. ► Nocturnin is rapidly induced in response to serum shock, LPS and other stimuli. ► Nocturnin functions in adipogenesis and lipid metabolism.