Quality control systems for aberrant mRNAs induced by aberrant translation elongation and termination

► Ribosome stall induces rapid decay of aberrant mRNAs and its products. ► A poly(A) tail plays a crucial role in nonstop mRNA quality control. ► Dom34:Hbs1 dissociates stalled ribosome and stimulates nonstop mRNA decay. ► E3 ubiquitin ligases are involved in proteasomal degradation of arrest product. ► A quality control system for aberrant ribosomes composed of nonfunctional rRNAs.