Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

► We provide an up to date list of TTP mRNA ligands described in the literature. ► We describe a list of TTP interacting proteins published to date. ► This review discusses how phosphorylation has been proposed to regulate TTP function. ► A model of TTP mediated mRNA decay is provided. ► A model is discussed of the proposed role of TTP to regulate mRNA translation.