Post-transcriptional control of gene expression by AUF1: Mechanisms, physiological targets, and regulation

► AUF1 is an RNA-binding factor that regulates expression of targeted transcripts. ► AUF1 binding is influenced by and impacts local RNA structure. ► AUF1 nucleates assembly of multi-subunit trans-acting complexes on RNA substrates. ► Many AUF1 target mRNAs encode clinically important factors. ► AUF1 expression, isoform distribution, and activity are tightly regulated.