Functional and molecular insights into KSRP function in mRNA decay

► KSRP is a multifunctional single strand nucleic acid binding protein. ► KSRP promotes the decay of labile mRNAs. ► KSRP post-transcriptionally controls gene expression at multiple levels. ► KSRP affects a wide range of innate immunity responses in mice. ► KSRP modular structure accounts for its ability to interact with multiple targets.