Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell

► We described the patterns of histone methylations under hypoxia and radiation in gastric cancer. ► The induced protein expression of JMJD2B through hypoxia was notably diminished after gamma-ray irradiation ► JMJD2B expression modulated by hypoxia and radiation regulated AGS cell proliferation through CCNA1 regulation. ► JMJD2B depletion caused the decrease of AGS proliferation under hypoxia