Activation of membrane-bound and soluble Toll-like Receptors 5 in Salmo salar depends on the MyD88 signalling pathway

In S. salar, activation of TLR5M and TLR5S is dependent on MyD88 as an adaptor protein after stimulation with flagellin. A sequential mechanism of activation, amplification and attenuation of the TLR5M/flagellin signalling pathway is proposed for this species. Our mathematical model is a robust predictive tool for generating new hypotheses about TLRs in S. salar.