Site-specific protein O-glycosylation modulates proprotein processing - Deciphering specific functions of the large polypeptide GalNAc-transferase gene family

► Up to 20 GalNAc-T isoforms catalyze the initiation of GalNAc-type O-glycosylation. ► O-glycosylation modulates proteolytic processing by PC convertases and ADAMs. ► Deficiencies in GalNAc-Ts cause protein specific effects and distinct phenotypes. ► New glyco-proteomic strategy for discovery of new targets of O-glycosylation/processing