Novel aminobenzyl-acetamidine derivative modulate the differential regulation of NOSs in LPS induced inflammatory response: Role of PI3K/Akt pathway

► LPS stimulation of H9c2 cells resulted in an opposite modulation of NOS isoforms. ► LPS induces iNOS through the activation of NF-kB nuclear translocation via NIK-IKKα/β‐IkBα. ► Effects of a new molecule as an anti-inflammatory modulator involving the PI3K/Akt pathway.