Mechanisms of divergent effects of activated peroxisome proliferator-activated receptor-γ on mitochondrial citrate carrier expression in 3T3-L1 fibroblasts and mature adipocytes

► PPARγ regulates CIC expression during fibroblast differentiation into fat cells. ► Activated PPARγ up-regulates CIC expression in fibroblasts, but not in adipocytes. ► In fibroblasts PPARγ ligand enhances the recruitment of PPARγ/Sp1/PGC1α、ARA70 coactivators to CIC promoter. ► In adipocytes PPARγ/Sp1/SMRT corepressor are recruited on CIC promoter. ► Divergent effects of PPARγ on CIC expression during adipogenesis are proposed.