White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma

► The omental fat of pheochromocytoma patients is subjected to a phenotypic switch toward BAT. ► PRDM16 is expressed by paucilocular adipocytes. ► Proliferation is a secondary, if present, contribution to tissue remodeling. ► White-to-brown adipocyte transdifferentiation seems to be the major phenomenon underlining the phenotypic change.