Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP)

► MAFP inhibits the lipase, phospholipase and galactolipase activities of HPLRP2. ► MAFP therefore inhibits both phospholipase A1 (HPLRP2) and A2 (cPLA2) activities. ► These findings provide additional evidence that MAFP specificity is weak. ► These findings challenge the common use of MAFP as an inhibitor of PLA2s.