Inhibition of lipid phosphate phosphatase activity by VPC32183 suppresses the ability of diacylglycerol pyrophosphate to activate ERK1/2 MAP kinases

► LPA receptor antagonist DGPP 8:0 stimulates ERK1/2 by unknown mechanism. ► DGPP effect is not mediated by LPA receptors. ► Lipid phosphate phosphatase dephoshporylates DGPP. ► LPA receptor antagonist VPC32183 inhibits DGPP dephosphorylation. ► LPP1 siRNA or VPC32183 suppresses DGPP-induced ERK1/2 activation.