Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS

► LC-MS/MS profiling of lipids in synovial fluid of rheumatoid arthritis patients. ► LC-MS/MS platform incorporating a ion trap MS and a core-shell particle column. ► Targeted investigation of pro-resolving lipid mediators in patient samples. ► Quantification of MaR1, 5S,12S-diHETE, RvD5 and LXA4 in synovial fluid. ► First description of pro-resolving lipid mediators in rheumatoid arthritis patients.