Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization

► Sterculic acid is a potent inhibitor of ER-stress induced by 7KCh. ► 7KCh is a potent inhibitor of SCD expression. ► SCD inhibition by sterculic acid is unlikely related to anti-inflammatory effects. ► The laser-injury rat angiogenesis model likely to be associated with 7KCh formation. ► Mechanistic data supports 7KCh's involvement in ER-stress related inflammation.