The role of lecithin:cholesterol acyltransferase in the modulation of cardiometabolic risks - A clinical update and emerging insights from animal models

► LCAT is a major modulator of HDL metabolism. ► Complete LCAT deficiency causes profound low HDL and modest hypertriglyceridemia. ► The role of LCAT in atherosclerosis remains controversial despite the dyslipidemia. ► Recent animal model studies revealed novel protective metabolic phenotypes. ► LCAT null mice are more insulin sensitive and resists diet induced obesity.