Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits

► We cloned rabbit LXRs cDNA. ► LXR activation in rabbits affect plasma lipid profiles in a different manner in rodents with no CETP activity. ► LXR agonist reduced atherosclerosis in rabbits, suggesting direct antiatherogenic effects mediated by induction of vascular gene expression.