The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells

► ABCA2 expression reduced membrane, total, free- and cholesterol ester levels. ► ABCA2 expression reduced cholesterol efflux to cyclodextrin and ApoE3. ► ABCA2 expression reduced esterification low-density lipoprotein-derived cholesterol. ► ABCA2 expression reduced low-density lipoprotein receptor (LDLR) levels. ► Silencing of endogenous ABCA2 expression increased LDLR protein levels.