ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity

► ChREBP was studied in human liver and adipose tissues in lean and obese patients. ► ChREBP mRNA and protein increased in the liver from obese patients. ► ChREBP mRNA levels in both adipose tissues decreased in obese individuals. ► Similar changes in the lipogenic enzyme FASN were observed in these tissues. ► ChREBP increases during differentiation of human preadipocytes in vitro.