کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8303602 1537943 2018 45 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain
چکیده انگلیسی
Linear ubiquitin chain is a latest discovered type of poly-ubiquitin chain that is broadly involved in innate immune and inflammatory pathways. Dysfunctions in its assembly, recognition or disassembly are intimately related with numerous immunodeficiency or autoimmune diseases. Our understanding of the molecular mechanism for linear ubiquitin chain formation, recognition and disassembly has being significantly evolved in recent years, with particular contribution from the biochemical and structural characterizations of related proteins. Here, we focus on the relevant proteins for the synthesis, recognition and digestion of linear ubiquitin chain, and review recent findings to summarize currently known molecular mechanism from a perspective of structural biology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1865, Issue 10, October 2018, Pages 1410-1422
نویسندگان
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