Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a specific substrate of yeast metacaspase

► GAPDH as a substrate of yeast metacaspase during H2O2-induced apoptosis. ► GAPDH fragmentation by metacaspase, during H2O2-induced apoptosis, is dependent on NO levels. ► GAPDH as a common substrate from yeast to mammalian cells upon apoptotic conditions.