کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8304105 1538380 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From the Ca2+-activated F1FO-ATPase to the mitochondrial permeability transition pore: an overview
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
From the Ca2+-activated F1FO-ATPase to the mitochondrial permeability transition pore: an overview
چکیده انگلیسی
Based on recent advances on the Ca2+-activated F1FO-ATPase features, a novel multistep mechanism involving the mitochondrial F1FO complex in the formation and opening of the still enigmatic mitochondrial permeability transition pore (MPTP), is proposed. MPTP opening makes the inner mitochondrial membrane (IMM) permeable to ions and solutes and, through cascade events, addresses cell fate to death. Since MPTP forms when matrix Ca2+ concentration rises and ATP is hydrolyzed by the F1FO-ATPase, conformational changes, triggered by Ca2+ insertion in F1, may be transmitted to FO and locally modify the IMM curvature. These events would cause F1FO-ATPase dimer dissociation and MPTP opening.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 152, September 2018, Pages 85-93
نویسندگان
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