کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8304414 | 1538406 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
In an effort to mimic in part the redundancy of satiety peptides involved in energy homeostasis, the combined benefits of the well-established satiety peptide CCK8 and an apparently anorectic peptide obestatin were studied in Swiss albino mice. The optimal dose of obestatin that was required to give the most pronounced effect with CCK8 was worked out by varying the concentration of obestatin while keeping CCK8 concentration constant at 200Â nmol/KgBW. Mice administered 160Â nmol obestatin and 200Â nmol CCK8 per kilogram body weight showed the most drastic reduction in food intake. Gain in body weight was arrested after day four during the eight day experiment. These studies reemphasize the beneficial effects imparted by co-administration of obestatin and CCK8 and their potential use towards countering obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 125, June 2016, Pages 126-130
Journal: Biochimie - Volume 125, June 2016, Pages 126-130
نویسندگان
ShreeRanga Nagaraj, Uma V. Manjappara,