Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target

Overview of VEGF and Epigenetics on HIF-1α regulation. In hypoxia, the activation of VEGF promoted the expression of HIF-1α. Meanwhile, epigenetics inhibit the expression of HIF-1α directly. In normoxia, the expression of HIF-1α was inhibited, the epigenetics changes promoted the expression of HIF-1α.138