Function of seipin: New insights from Bscl2/seipin knockout mouse models

This review analyses how these studies using Bscl2−/− mice brought new insights into seipin function and the mechanisms involved in the pathophysiology of BSCL. We also analyse some of the human data in the light of the mouse phenotyping and discuss the validity of Bscl2−/− mice model to test pharmaceutical approaches for treating BSCL and its associated metabolic complications.