کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8309676 | 1538619 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated systemic zonula occludens 1 is positively correlated with inflammation in cirrhosis
ترجمه فارسی عنوان
افزایش انسداد زنجولهای سیستمیک 1 با التهاب در سیروز ارتباط مثبت دارد
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کلمات کلیدی
hs-CRPZonula occluden-1γGTZO-1IFN-γALTiNOSSBPAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییhepatic encephalopathy - آنسفالوپاتی کبدیtight junctions - اتصالات محکمinflammation - التهاب( توروم) interferon - اینترفرونinterleukin - اینترلوکینinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییNitric oxide - نیتریک اکسیدhigh sensitivity C-reactive protein - پروتئین واکنش پذیر C با حساسیت بالاTight junction protein - پروتئین پیوند تنگspontaneous bacterial peritonitis - پریتونیت باکتریایی خودبه خودیgamma glutamyl transferase - گاما گلوتامیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
It has been well established that disruption of the intestinal barrier function and increased intestinal permeability contribute to endotoxemia and associated liver injury in patients with cirrhosis. However, the relationship between systemic inflammation and tight junction protein in cirrhosis remain unidentified. The aim of this study was to assess and compare the blood concentrations of ZO-1 with systemic hsCRP in patients with cirrhosis and healthy individuals. Methods: 30 cirrhotic patients and 30 healthy individuals were enrolled in the study. Blood ZO-1 and hsCRP were measured by ELISA and biochemical parameters by AU680 Beckman Coulter (USA) autoanalyser. Results: The serum ALT, AST, bilirubin, gamma GT, ALP and ammonia were significantly (Pâ¯<â¯0.0001) elevated whilst serum albumin concentration was decreased in cirrhotic patients when compared to healthy individuals. Systemic tight junction protein ZO-1 concentration [590.0â¯Â±â¯32.79 vs. 349.9â¯Â±â¯18.76â¯pg/ml, respectively; Pâ¯<â¯0.0001] and hsCRP [10.50â¯Â±â¯1.05 vs 5.31â¯Â±â¯0.65â¯mg/L, respectively; Pâ¯<â¯0.001] were significantly elevated in patients with cirrhosis compared to controls. Significant positive correlation was found between increased ZO-1 and hsCRP (râ¯=â¯0.2680 Pâ¯<â¯0.01). Conclusion: Our results suggested that increased systemic ZO-1 concentration was associated with inflammation in cirrhosis. Thus, elevated blood ZO-1 levels could be a prognostic marker of cirrhotic patients with intestinal TJ disruption on the background of inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 480, May 2018, Pages 193-198
Journal: Clinica Chimica Acta - Volume 480, May 2018, Pages 193-198
نویسندگان
Ashwini Karthikeyan, Pazhanivel Mohan, Palanivel Chinnakali, Balasubramaniyan Vairappan,