کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8309771 | 1538622 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays](/preview/png/8309771.png)
چکیده انگلیسی
We report here an interference that has been observed with 2nd generation PTH assays (PTH2), but not with 3rd generation PTH ones (PTH3), during PTH monitoring occurring in a surgical intervention for the resection of a parathyroid adenoma. The patient was cured and calcium levels returned to normal the next day, but PTH did not decrease with PTH2 whereas it decreased by 50% with PTH3 assays during the intervention. The reason is probably a PTH fragment released by the parathyroid gland during surgery. This fragment possesses the C-terminal part of the peptide but lacks the first amino-acids and may thus be considered as a member of the non-(1-84) PTH fragments family. It has also a longer half-life than 1-84 PTH. To avoid reporting spurious results to the surgeons, we thus recommend using PTH3 assays for monitoring of intra-operative PTH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 477, February 2018, Pages 72-73
Journal: Clinica Chimica Acta - Volume 477, February 2018, Pages 72-73
نویسندگان
Etienne Cavalier, Marie-Louise Schleck, Jean-Claude Souberbielle,