Oxidative stress-mediated (sex-specific) loss of protection against type-2 diabetes by macrophage migration inhibitory factor (MIF)−173G/C polymorphism

MIF− 173GC polymorphism independently contributes to abdominal obesity and is related to apoB concentrations apparently in men alone. Tendency of the − 173C-allele carriage to predict new-onset diabetes independently was also confined to men. These gender-modulated associations suggest novel gene-gender-environmental interactions originating from a proinflammatory state.