Decrease in circulating autotaxin by oral administration of prednisolone

► ATX levels were measured in autoimmune disease patients before and after PSL therapy. ► ATX levels in serum of patients showed an inverse correlation with PSL dosage. ► During tapering of PSL dosage, ATX levels increased, independent of disease activity. ► Decreased ATX levels during PSL treatment correlated with decreased lysoPLD activity. ► PSL treatment decreased ATX mRNA levels in cultured murine adipose tissue.