Is there a link between endothelial dysfunction, coagulation activation and nitric oxide synthesis in preeclampsia?

► Preeclampsia is associated with endothelial dysfunction and coagulation activation. ► Endothelial dysfunction results in thrombomodulin release. ► D-dimer is a marker of fibrin formation and degradation. ► NO is involved in various stages of successful pregnancy. ► Reduced NO may contribute to endothelial dysfunction and coagulation activation.