Genetic variant rs623011 (17q24.3) associates with non-familial thyrotoxic and sporadic hypokalemic paralysis

► Non-familial TPP and SPP feature acute hypokalemia and muscle paralysis. ► TPP and SPP may reduce Kir current in skeletal muscle. ► A variant rs623011 potentially modifying the expression of Kir2.1 is present in both TPP and SPP.