Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: A serum metabonomic study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm

► Serum metabolic profiling of ergone therapeutic CRF rats was developed by UPLC-HSMS. ► The alterations were associated with amino acids and phospholipid metabolism. ► Metabonomics is helpful in understanding the therapeutic effect mechanism of CRF.