Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population

► We examined correlation between nsSNPs of BER genes and melanoma risk and/or aggressiveness. ► We found that two XRCC1 nsSNPs (rs25487 and 25489) showed a strong correlation with melanoma risk. ► We found a strong influence of age as protective factor. ► Our study did not show any association between single BER nsSNP and MM aggressiveness.