A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique

► Metabonomics was employed to screen and identify novel biomarkers of gout. ► The acute gout shows the dysfunctions of purine, protein and glucose metabolism. ► The metabolizing of guanosine to UA increases the levels of serum UA at the acute. ► Tryptophan in serum has been identified as the novel biomarkers of gout.