Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis

►Increased serum concentrations of pigment epithelium-derived factor (PEDF) have been linked to metabolic alterations. ►Serum PEDF levels are significantly increased in patients with biopsy-proven NAFLD. ►PEDF levels were the main independent predictors of steatosis scores.