Analysis of the GAD65-GAD65 autoantibody interaction

Overall, our study indicated that GAD65Ab in different patients studied showed similar association and dissociation rate constants and similar affinity constants. However, GAD65Ab concentrations vary widely between different sera. There was a modest reduction of the median binding of GAD65Ab to GAD65 E517P in the group of patients with type 1 DM compared to patients without type 1 DM.