کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8319799 | 1539344 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
When your cap matters: structural insights into self vs non-self recognition of 5â² RNA by immunomodulatory host proteins
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5â², including the 5â² cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5â² RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 36, February 2016, Pages 133-141
Journal: Current Opinion in Structural Biology - Volume 36, February 2016, Pages 133-141
نویسندگان
Daisy W Leung, Gaya K Amarasinghe,