Polyproteins in structural biology

- Structures have been determined for natural and recombinant polyproteins.
- Native HIV Gag polyprotein architecture was revealed by cryo-EM of immature capsids.
- Recombinant polyprotein technology has resolved sample preparation bottlenecks.
- The high-resolution structure of influenza polymerase has been solved.
- Single-molecule analysis of polyproteins revealed their folding characteristics.