Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins

- Missense mutations frequently alter protein biophysical characteristics such as stability, dynamics and interactions.
- Protein biophysical properties are interrelated and diseases often result from simultaneous changes of several properties.
- Magnitude and direction of the change cannot be directly implicated to the phenotype and disease risk.
- Disease-causing mutations tend to cause large changes in the physico-chemical properties of the mutation site.