Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers

- Substitution of canonical histones with variants is crucial for nucleosome function.
- Variant H2A-H2B dimers are recognized and substituted as a distinct unit.
- H2A/H2B variants may preferentially associate with each other.
- L1/L2 loops within H2A histone fold have increased sequence and structural variability.
- Variant nucleosomes have altered structural and interaction properties.