Inhibition of protein aggregation and amyloid formation by small molecules

- We review recent drugs mainly targeting Aβ and how they were identified.
- We report their results from in vitro and in vivo experiments and clinical trials.
- We describe simulation results on how inhibitors interact with Aβ species.
- Macromolecular crowding should be treated in simulations.
- How Aβ mutations at residue 2 protect from Alzheimer remains unknown.