Extracellular modulators of Wnt signalling

- Structure and binding of lipid-modified Wnt8 with Frizzled8 cysteine-rich domain.
- Modularity of Wnt inhibitory factor 1 combining Wnt-binding and heparan sulphate-binding.
- Integration of multiple interaction sites in LRP5/6 ectodomain architecture.
- Ternary complex assembly of RNF43/ZNRF3 and LGR4/5/6 bridged by R-spondin.
- Ectodomain dimerisation of the Frizzled-specific E3 ligase ZNRF3.