Myosin chaperones

- UCS proteins comprise a diverse family of myosin chaperones.
- UCS chaperones differ in their substrate targeting, folding and activation mechanism.
- TPR-less UCS chaperones dimerize to control the myosin-actin interaction.
- TPR-containing UCS proteins compose multimeric assembly lines for myofilaments.
- Misregulation of UCS activity is linked to myopathies including heart diseases.