کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8320319 1539360 2018 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA damage and oxidative stress in long-lived aquatic organisms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
DNA damage and oxidative stress in long-lived aquatic organisms
چکیده انگلیسی
The maintenance of genomic integrity through the DNA repair processes is essential for proper cellular metabolism, growth, and development. DNA damage plays a key role in mutagenesis and the development of cancer. The cellular DNA damage response activates complex signaling pathways that may promote not only DNA repair and survival but also can trigger cell suicide. Exceptionally long-lived animals may allow explaining the mechanisms of healthy aging without cancer. One of the particular emphases of this review is the link between oxidative stress, DNA repair pathways, and longevity. We specifically focus on the long-lived aquatic organisms, which provide a novel understanding of both healthspan and lifespan despite high oxidative stress caused by environmental factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 69, September 2018, Pages 14-23
نویسندگان
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