کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8320798 1539406 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Remarkable induction of UV-signature mutations at the 3′-cytosine of dipyrimidine sites except at 5′-TCG-3′ in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Remarkable induction of UV-signature mutations at the 3′-cytosine of dipyrimidine sites except at 5′-TCG-3′ in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice
چکیده انگلیسی

- UVB-induced mutation in the skin epidermis of Polh−/− mouse was analyzed.
- UVB induced remarkably more mutations in Polh−/− than in Polh+/+ and Polh+/− mice.
- UV-signature mutations were predominant in the Polh−/− mutation spectrum.
- Sequence context preferences of the mutations in Polh−/− and Polh+/+ were different.
- Minor but significant recoveries of G → T transversion were observed in Polh−/− mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 22, October 2014, Pages 112-122
نویسندگان
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